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Geochemical characteristics of mineralized waters of Central Eastern Lombard Prealps (Italy) have been studied with specific attention to processes that originate waters with a complex composition. To achieve the objectives of this study, 34 samples of mineral waters were collected in the area of interest. These samples were analyzed for determination of main cations, anions and some trace elements. Elaboration of analytical data allowed to classify the waters, to identify geochemical processes that originate them and to simulate reaction paths of the different water groups. Reaction paths have been simulated with PhreeqcI geochemical software related to: (i) the evolutionary paths related to the dedolomitization process that starting from with bicarbonate-calcium waters originates sulphate-calcium waters with high magnesium contents (Boario, Angolo, Tartavalle and Salice di Prestine mineral waters), (ii) the processes that generate sulphate-calcic waters that flow from the chalky outcrops of the Brembana and Camonica valleys and (iii) the processes that give rise to the basic sulphurous waters with bicarbonatesodium composition of the Imagna, Brembilla and Cavallina valleys. Finally, by means of geothermometric techniques and mixing models, San Pellegrino and Bracca thermal waters have been studied: temperature of the thermal reservoir that feeds them has been calculated and its depth has been estimated based on local geothermal gradient.